A new magnetite Pd-nanoparticle supported (4,5-diazafluoren-9- one)-derived palladium chloride (7) was synthesized, characterized and introduced. The nanocatalyst exhibited an efficient activity in Suzuki cross-coupling reactions with an environmentally-friendly (H2O/DMF) solvent system for 1–3 h at 100 C and Mizoroki–Heck cross-coupling reactions. The catalyst can easily be recovered from the reaction system by using an external magnet and reused several times with high yields