Abstract The present study aimed to investigate the efectiveness of enhanced cognitivebehavioral group therapy (CBT-E) on negative perfectionism (NP), self-criticism, and self-compassion in female college students. The method of the present study was quasi-experimental with a pretest–posttest control group design. The statistical population included all female college students with NP, high self-criticism, and low self-compassion attending universities in Hamadan, Iran. Of college students who referred to the counseling center of Bu-Ali Sina University, Hamadan, in 2019–2020 academic year, 30 were selected based on the scores obtained in the questionnaires of Hill’s Perfectionism, Clark et al.’s self-criticism, and Nef’s self-compassion by purposive sampling and randomly assigned into two groups. The experimental group underwent eight weekly 120-min sessions of CBT-E. Univariate analysis of covariance (ANCOVA) was used to analyze the data in SPSS-21. The results revealed that CBT-E signifcantly reduced NP and self-criticism and signifcantly increased self-compassion in the posttest, which indicates the efectiveness of this treatment in female college students.