Background and Aim: The purpose of this study is the comparison of interpersonal sensitivity and obsessive - compulsive of methadone receivers and DIC office receivers on Drop in Center, Hamedan. Methods: Method of this research is cross sectional. Statistical population was persons that refer to center for addiction in Hamedan, 2011. Of them 60 people were selected byconvenient sampling (30 people methadone receivers and 30 people DIC services receivers) and answered to SCL-90 test. The data was analyzed by SPSS software and independent T-test. Results: Results demonstrated that there is a significant difference between interpersonal sensitivity and obsessive - compulsive of methadone receivers and DIC office receivers (P < 0/001). Conclusion:Therefore, methadone maintenance treatment is more effective than DIC office and it improves mental health of clients.
