Chemical kinetics has been widely acknowledged as a fundamental theory in analysis of chemical processes and the corresponding reaction outputs and rates. The study and application of chemical kinetics thus provide a simulation tool to predict many characteristics a chemical process. A simple way to kinetics study is absorbance measurement by wavelengths scanning that creates a two-way data set and analysis of data using proper chemometrics methods. There is a powerful class of methods based on rank annihilation factor analysis (RAFA). RAFA is based on rank analysis for two-way spectral data and can be employed to analyses quantitatively “gray system” with unknown background. In this study the kinetics of the reaction of the chlorpheniramin with iodine in organic solvents has been investigated from the two-way kineticspectral data obtained through the charge transfer complex formation. Rate constants in three solvents was measured by RAFA approaches. Variation in the kinetic constants were in complete agreement with the model proposed and the solvent polarities. Also soft modelling exploratory data analysis such as evolving factor analysis (EFA) and multivariate curve resolutionalternating least squares (MCR-ALS) used for getting information about the number of species as well as concentration and spectral profiles of each individual species involved in the multivariate monitored process. The methods were obtained good results.
