The purpose of this study was to develop a structural model of emotional divorce (ED) based on neuroticism mediated by coping strategies and emotional regulation. The study was of descriptive-correlational type based on structural equation modeling. The statistical population included all married female teachers working at schools of Hamedan, Iran in 2019, among whom 300 were selected using the cluster sampling method. Data were analyzed using structural equation modeling. The results indicated that the proposed model had a good fit, which means that neuroticism can predict ED through themediating role of coping strategies and ER. Neuroticism predicted ED negatively through reappraisal (P < .05) and problemfocused coping strategy (P < .01), positively through emotion suppression (P < .01), emotion-focused coping strategy (P < .01),and avoidance coping strategy (P < .01). Considering the role of neuroticism, coping strategies, and emotional regulation in ED, it would be practical and effective to address these factors inpremarital counseling and training and future research.