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Javad Saien

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
HIndex:
Faculty: Faculty of Chemistry and Petroleum Sciences
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Research

Title
Grafting Drugs to Functionalized Single-wall Carbon Nanotubes as a Potential Method for Drug Delivery
Type
JournalPaper
Keywords
Single wall carbon nanotube, Kinetic, Drug release, SWCNT-drug grafting
Year
2021
Journal Physical Chemistry Research
DOI
Researchers ، Ardeshir Khazaei ، Javad Saien

Abstract

The mesalazine and fluvoxamine drugs were grafted to single-walled carbon nanotubes (SWCNTs) aiming at precise drug delivery. First, carboxylic groups in SWCNT were converted to corresponding acyl chlorides. Next, in order to form the amide bonds, acyl chloride- SWCNTs were mixed with chemotherapeutic agents having NH2 and NH functional groups. Then, the covalently grafted drugs to SWCNT were characterized by UV-Vis, IR spectroscopy, and transmission electron microscopy methods. Finally, the prepared organic compounds were used for releasing drugs at pH: 1.3, which is corresponding to clinical aspects of the human body, and were examined for the potential of drug delivery in patients. Accordingly, the in-vitro kinetic as well as the mechanism of the released drugs were investigated.