Background and Aim: Colon carcinoma is a common malignancy, one of the leading causes of cancer-related deaths worldwide. And the recognition of new biomarkers is an important strategy in diagnosing the disease and effectively reducing the mortality of this disease. Exosomes are extracellular macrovesicles released from cells, which are involved in many biological and pathological processes, mainly because of their role in the relationship between Cells are involved. Exosomes derived from colon carcinoma cells are associated with oncogenesis, tumor cell survival, resistance to chemotherapy and metastasis. The aim of this study is to review the role of exosomes in colon carcinoma. Methods: This study is a review study by searching scientific databases such as Scopus, PubMed, Google Scholar, and Embase from 2015 to 2023 by using the keywords Colon carcinoma, exosomes, biomarker, tumor genesis, 73 articles related to inclusion criteria were extracted and then analyzed. Results: The results indicated that some RNAs and different proteins expressed in exosomes play a key role in the initiation and development of colon carcinoma and are potential candidates for the diagnosis of malignancy. Conclusion: Recently, many efforts have been made to identify useful biomarkers in colon carcinoma, and colon carcinoma exosomes have potential applications as a means of carrying genetic modulators, protein, RNA, and drugs to target cells for clinical applications. However, more studies are needed to deepen the knowledge of colon carcinoma exosomes and its clinical implications.
