BACKGROUND AND OBJECTIVES The digestive system is crucial for animal health, converting food into nutrients for energy, development and tissue repair. Obtaining methods to increase and improve the function of the digestive system, optimizes productivity, growth, reproductionand milk production. MATERIALS AND METHODS Data about the role of gut microbiome in animal health and disease were gathered using scientific search engines including Web of Science, Wiley Online, Science Direct, Scopus, and Google Scholar. RESULTS AND DISCUSSION The gut microbiota has a critical role in regulating metabolism, sustaining the immune system and avoiding disease in animals. It is essential for digestion, absorption and energy metabolism in dogs, cats and agricultural animals. According to recent studies, The health of farm animals may also be evaluated using the gut microbiome, Dysbiosis might be treated by employing techniques such as faecal microbiota transplantation (FMT). So, dysbiosis can be caused by by a variety of reasons, such as: antibiotic therapy , stress and eating environmental contaminants.Unbalances in the gut microbiome have been related to a number of disease in animals, such as gastrointestinal (GI) disorders, obesity, metabolic disorders, immunological disorders inflammatory bowel disease (IBD) and neurobehavioral disorders. Use of probiotics and prebiotics can help animals' gut microbiomes. The health of the host animal is improved by probiotics such as Acidophilus Lactobacillus, Faecal Enterococciand Bacillus species, which enhance the microbial balance in the gut. Prebiotics that support the growth and activity of beneficial bacteria in the gut include: Fructooligosaccharides (FOS), Galactooligosaccharides (GOS) and Mannan oligosaccharides (MOS). CONCLUSION So maintaining the balance of the microbiome plays a significant role in the health of the digestive system in animals
