حسین رضوان

Background: Cutaneous leishmaniasis is one of the endemic and common diseases in many countries of the world, including Iran. The use of glucantim is the most important treatment method for cutaneous leishmaniasis, which has many side effects. The aim of this study is to present a herbal treatment method with the effective ingredient of non-alcoholic garlic extract for cutaneous leishmaniasis. Materials and methods: In this study, female BALB/c mice aged 6-8 weeks were infected with the standard strain of Leishmania major. A group of animals received garlic extract (0.6 g/bw/kg) before the appearance of a wound and a group received garlic extract together with the drug glucantim (18mg/kg/bw) and another group received garlic as an ointment (1-2 g/lesion). After 123 days of the treatment period, the size of the wound, the death rate of the animals and the healing process of the wound through the examination of tissue sections of the skin, liver, spleen and lymph nodes were investigated in weeks (2, 4, 6, 8, 10, 12). Result: The size of the lesion decreased in the group receiving garlic extract orally during the treatment compared to the group treated with glucantim and garlic extract by topical method (P-Valu <0.05). The percentage of survival of the mice that received the extract as an ointment was significantly higher than the other treated groups (P-Valu <0.001), according to the pathology findings, there was no edema and severe inflammation in the group that received the extract of garlic. Significant reduction of tissue damage were seen in dermis and hypodermis of the skin. Also, granulomas in the liver, the return of the microscopic structure of the lymph node to the normal state and the regeneration of the white pulp in the spleen were observed. Conclusion: The lesion healing process of cutaneous leishmaniasis in the groups receiving garlic extract orally is significant compared to the group receiving it topically and it has a synergistic effect in the groups