Identifying the factors affecting drinking water consumption is essential to the rational management of water resources and effective environment protection. In this study, the effects of the factors on rural drinking water demand were studied using the adaptive neuro-fuzzy inference system (ANFIS) and hybrid models, such as the ANFISegenetic algorithm (GA), ANFISeparticle swarm optimization (PSO), and support vector machine (SVM)esimulated annealing (SA). The rural areas of Hamadan Province in Iran were selected for the case study. Five drinking water consumption factors were selected for the assessment according to the literature, data availability, and the characteristics of the study area (such as precipitation, relative humidity, temperature, the number of subscribers, and water price). The results showed that the standard errors of ANFIS, ANFISeGA, ANFISePSO, and SVMeSA were 0.669, 0.619, 0.705, and 0.578, respectively. Therefore, the hybrid model SVMeSA outperformed other models. The sensitivity analysis showed that of the parameters affecting drinking water consumption, the number of subscribers significantly affected the water consumption rate, while the average temperature was the least significant factor. Water price was a factor that could be easily controlled, but it was always one of the least effective parameters due to the low water fee.