Smart hydrogels are soft materials which can be applied in sensors and actuators especially in microfluidics in which the fluid–structure interaction is important. In this work, first, the behavior of a one-way hydrogel micro-valve is investigated by considering the fluid–structure interaction effect for a specified geometry of the micro-valve. Second, both the fluid–structure interaction and non-fluid–structure interaction simulations are conducted to study the fluid flow effect on the operational parameters of the micro-valve. The obtained results show that the fluid–structure interaction effects are important and have a considerable influence on the micro-valve parameters especially on its closing temperature. Thereafter, a precise study on the micro-valve is executed by considering the micro-valve operational parameters such as inlet pressure, head size, crosslinking density, and breaking pressure at different temperatures. The results show the importance of considering the fluid–structure interaction effect in the design of these devices.
