In this study, a PVC membrane electrode modified with a Cd Schiff base complex was constructed as a novel, sensitive and selective structured carrier for checking trace amounts of mefenamic acid in real samples. A novel macrocyclic Schiff base complex ([CdL2Cl]ClO4$2H2O) was synthesized via the Cd(II) templated [1 + 1] cyclocondensation of 2,9-dicarboxaldehyde-4,7-diphenyl-1,10-phenanthroline with N-(2-aminoethyl)-1,3-propanediamine. The effects of the parameters such as working solution pH, repeatability, reproducibility, response time and selectivity to mefenamic acid were investigated. This sensor responds to mefenamic acid in the wide linear range from 1.0 109 to 4.0 102 mol L1 with a limit of detection of 5.01 109 mol L1 at pH 3–8.5. The proposed sensor has a fast response time and can be applied for at least 5 months without any significant divergence in the currents.
