Recent studies about innovations in GO/N-Ligand-Cu Nano-Composites have been done. Graphene-Oxide is improved with N1 ,N3 -bis (pyridin-2-ylmethyl) propane-1,3-diamine and after that is matched with copper (Cu). The chemical composition and the structure of the catalyst were analyzed by TGA/DTG, EDX, XRD, FT-IR, TEM, and SEM. The results demonstrated that GO/NLigand-Cu was able to catalyze the chromeno[2,3-b]pyridine compounds to obtain high yields in short reaction time. The results of the present work are hoped to assist the growth of a new class of heterogeneous catalysts as the high-function candidate for industrial applications.