Thermodynamic properties such as apparent molar volume, 𝐯φ and apparent molar isentropic compressibility, 𝑘ⱷ𝓈 for aqueous solutions of glycine, histidine, and valine in nortriptyline corresponding measured their density as well as speed of sound at T = (305.15, 310.15, and 315.15) K were computed. The obtained quantities were discussed in terms of interactions between drug-water and amino acids which was due to specification structural and upon the situation of nortriptyline molecules.
