In order to study the stochastic Markov processes conditioned on a specific value of a time-integrated observable, the concept of ensembles of trajectories has been recently used extensively. In this paper, we consider a generic reaction–diffusion process consisting of classical particles with nearest-neighbor interactions on a one-dimensional lattice with periodic boundary conditions. By introducing a time-integrated current as a physical observable, we have found certain constraints on the microscopic transition rates of the process under which the effective process contains local interactions; however, with rescaled transition rates comparing to the original process. A generalization of the linear Glauber model is then introduced and studied in detail as an example. Associated effective dynamics of this model is investigated and constants of motion are obtained.