Sulfonamides are a large class of antibiotics that interfere with the bacterial synthesis of folic acid from p-aminobenzoic acid[1-2]. Electrochemistry also, is a powerful tool for the synthesis of complex organic compounds that covers most of 12 principles of green chemistry[3]. In this work a new sulfonamide derivative was synthesized by the electrochemical oxidation and chemical reaction of 4-nitroso-N,N-dimethylaniline in the presence of sodium sulfite as nucleophiles(scheme1). Both processes are practically convenient to carry out and can be performed at atmospheric pressure and room temperature. The electrochemical synthesis was carried out in water at pH=2 and gave the product in 60% yield. The chemical synthesis, carried out in water at pH =5, provided the product in 77% yield. Neither catalyst nor organic/inorganic oxidizing agents are necessary and the reaction can be performed under sustainable and green conditions. furthermore products were evaluated for its in vitro antibacterial activity. It was found that the some of tested compounds were active against Gram-negative bacteria.
