Effluents of a large variety of industries usually contain important quantities of synthetic organic dyes. The discharge of these colored compounds in the environment causes considerable non-aesthetic pollution and serious health-risk factors.Electrochemical oxidation or electro-oxidation (EO) is the most popular electrochemical procedure for removing organic pollutants from wastewaters [1]. Indirect electro-oxidation removal of p_Xylenolsulfonphthalein (p-Xylenolblue) from aqueous solutions has been studied. The study showed average of removal efficiency is 88.92%. Sodium chloride was used as supporting electrolyte. Cyclic Voltammetry and Ultraviolet Spectroscopy used for removal efficiency calculation. Obtaining optimum conditions; six parameters in five level was studied. For this reasonTaguchi experimental design (L25 orthogonal array) used. Parameters are: initial pH, supporting electrolyte concentration, current dencity, electrical charge, initial dye concentration and electrode material. The results have been analyzed using signal-tonoise (S/N) ratio and analysis of variance (ANOVA). According to statistical data electrode material and electrical charge are the most significant parameters.