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Hydralazine (HYD) (1-hydrazinylphthalazine) is a directacting vasodilator. This is done by directly relaxing the smooth muscles in the blood vessels [1,2]. The synthesis of HYD is often carried out by the reaction of phthalazinone with POCl3 and hydrazine hydrate [3-5] . A lot of work has been done to synthesize new HYD derivatives, which are completely based on the nucleophilicity of HYD. However, a literature survey reveals that unlike these reports [5-7], no paper has reported the late-stage modification of HYD based on its electrophilicity. In this work, we were able to do this by changing the nature of HYD from nucleophile to electrophile . In this work, the late-stage modification of HYD was performed by oxidizing it at the anode surface and converting it from a nucleophile to an electrophile. The results show that HYD changes into its oxidized form (electrophile) by losing two electrons and two protons. Then the generated electrophile reacts with nucleophiles and produces the desired product. In this research, arylsulfinic acids (ASA) were used as nucleophiles and new derivatives of sulfonylhydrazine (SHD) were provided .(Figure 1) The synthesis of these molecules has been carried out through the electrochemical oxidation of HYD in the presence of ASA. Sulfonylhydrazines are an important class of compounds with significant antimicrobial and antineoplastic activities [8]. Synthesized sulfonylhydrazines have a specific structure consisting of three parts. Since all three parts have known medicinal properties, it is expected that the synthesized molecules also have specific biological and pharmacological activities. This expectation is our motivation for synthesizing these molecules in this study. The synthesis of these molecules has been carried out through the electrochemical oxidation of HYD in the presence of ASA.