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Isoniazid (ISO) is an antibiotic drug that works by inhibiting the synthesis of mycolic acids, which are essential components of the cell wall of tuberculosis-causing bacteria[1,2]. Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used to treat tuberculosis. For active TB, it is often used in combination with rifampicin, pyrazinamide, and streptomycin or ethambutol. For latent TB, it is often used alone[3,4].It may also be used for unusual types of mycobacteria such as M. avium, M. kansasii and M. xenopi. The most common method of synthesizing isoniazid involves the reaction of isonicotinic acid with hydrazine in a condensation reaction[5]. A lot of work has been done to synthesize new ISO derivatives, which is completely based on the nucleophilicity of ISO among these reactions, we can mention ISO reaction with compounds such as aldehydes, aryl halides, and ketones. However, the literature review shows that, contrary to these reports, no paper has reported the final stage modification of ISO based on its electrophilicity. In this work, we were able to do this by changing the nature of ISO from a nucleophile to an electrophile. Changing the nature of nucleophile to electrophile is one of the capabilities of electrochemical methods, which is done by removing an electron from a nucleophile