Abstract A novel adenine-based palladium nano-complex was synthesized via preparation of the Fe3O4 magnetic nano-particles (Fe3O4 MNPs), coating with tetraethyl orthosilicate, functionalization with both 3-chloropropyltrimethoxysilane (CPTMS) and adenine (AD) ligands and fnally formation of the corresponding complex by PdCl2 (Fe3O4@SiO2@CPTMS@AD@ Pd). Then, it was characterized with diferent methods such as FT-IR, EDX, ICP, XRD, SEM, TEM, VSM and TGA-DTA techniques, and capability of the adenine-based Pd complex evaluated by its application as an efcient heterogeneous nano- catalyst for the synthesis of various N-mono-substituted ureas in water by hydrolysis of cyanamides in the presence of 98% HCOOH with good to high yields in relatively short reaction times at room temperature.
