Semicarbazide (SC) is a derivative of urea that is of remarkable interest because of its chemistry to form stable chelates with essential metal ions and potentially beneficial biological activities, such as antitumor, anti-bacterial, antiviral, and antimalarial.[1] Magnetic nanoparticles (MNPs), a type of alternative support or catalyst-supported material, have been recently explored extensively.[2] Among iron oxide magnetic nano-particles, sulfonic acid-functionalized magnetic nanoparticles (SAMN), known as the recoverable solid strong acid, have attracted much attention due to economically important and environmentally benign features.[3] Pyranopyrazoles have received considerable attention due to the wide range of biological activities such as anti-cancer, antileishmanial, antimicrobial, anti-inflammatory, lactamase inhibitor, etc.[4-5]
