Polypropylene membrane with the base of polyolefin exhibits promising applications such as packaging, medical tools, and especially in the filtration industry, due to its outstanding properties such as well mechanical features, recyclability, acceptable resistance to temperature and chemicals, and reasonable price. However, its applications are restricted by its hydrophobic nature. To amend the surface physical and chemical properties of polypropylene and broaden its usage, well-known methodologies such as laser modification and plasma irradiation have been investigated more than the other methods. Herein, in this chapter, the investigations on the surface refinement of polypropylene using laser and plasma are discussed. Furthermore, a comparison between the effectiveness of both methods (i.e. laser modification and plasma irradiation) is presented.