The effects of nano-TiO2 on growth indices and antioxidant enzyme activity of camelina seedlings under sodium nitroprusside and salinity stress was investigated in a factorial experiment with four replications in the crop physiology research laboratory of Bu-Ali Sina University. Nano titanium dioxide was studied at 500, 1000, and 2000 mg/L under 50 and 100 Mm sodium chloride salinity with 100 μM sodium nitroprusside and control. Salinity stress declined the growth characteristics and germination indices such as, germination percentage, germination rate, mean germination time, vigor index, radicle length, shoot length and the membrane electrolyte leakage increased. In the presence of nano-TiO2, most of germination indices improved and activity of CAT, APX and SOD enzymes increased. Sodium nitroprusside decreased the adverse effects of salinity stress and adjusted the membrane electrolyte leakage. Also, the interaction effect of sodium nitroprusside and nano-TiO2 was significant on the most studied traits. Nano-TiO2 (1000 mg/L) with 100 μM SNP improved SOD, APX and CAT enzyme activities under 100 Mm salinity stress. According to the results, it seems that sodium nitroprusside diminished the adverse effects of salinity stress and impressed the nano-TiO2 performance on camelina germination indices and antioxidant enzymes content.