A proper monitoring of stochastic systems is the control charts of statistical process control and drift in characteristics of output may be due to one or several assignable causes. Although many research works have been done on the economic design of control charts with single assignable cause, the economic statistical design of T2 control chart under Weibull shock model with multiple assignable causes and considering multivariate Taguchi loss function has not been presented yet. Using Taguchi loss function in the concept of quality control charts with economic and economic statistical design leads to better decisions in the industry. Based on the optimization of the average cost per unit of time and taking into account the di erent combination values of Weibull distribution parameters, optimal design values of sample size, sampling interval and control limit coe- cient were derived and calculated. Then the cost models under non-uniform and uniform sampling scheme were compared. The results revealed that the model under multiple assignable causes with Taguchi loss function has a lower cost than single assignable cause model and integrated model with non-uniform sampling has a lower cost than that with uniform sampling.