Asthma is an obstructive pulmonary disease caused by immunogenic and nonimmunogenic agents. It is mostly prevalent in autumn and winter seasons resulting in hospitalization of the patients. In the present study, 281 hospitalized asthma cases stayed at Sina hospital Hamadan from 2010 to 2015 were evaluated. The total prevalence rate of Asthma in women was 66% and in men was 33%. 1- The maximum prevalence rate was for year 2015 (21.35%). 2- Statistically the rate of the disease from 2010 to 2015 was increasing. 3- The maximum rate of the disease in women was in 2010 (85.71%) and for men was in 2013 (43.13%). The maximum prevalence rate for asthma was in winter at 32.38% and the minimum prevalence rate of the disease was in summer at 16.73%. In sum, the prevalence of pulmonary diseases is probably up-regulated in cold seasons and that during these seasons asthma in the patients increase. On the other hand, the gender and aging can affect asthma symptoms in women and immunologic and non-immunologic stimulators can increase the prevalence rate of asthma.