In this work glassy carbon electrode (GCE) was modified with copper terephthalic metal-organic frameworkmulti-walled carbon nanotubes (MWCNTs/Cu (TPA) MOF) nanocomposites and used as a simple and sensitive sensor for levodopa (LD). This method is based on LD oxidation at GCE surface modified with (MWCNTs/Cu (TPA) MOF) nanocomposites. MOF was synthesized with the hydrothermal method. The synthesized MOF was characterized by Field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD). For modification of GCE, suspension of MOF and MWCNTs in ethanol was dropped on surface of GCE. Electrochemical studies were accomplished by square wave voltammetry (SWV). The applied MOF, as a Cu-containing synthetic peroxidase enzyme, can electrocatalyze oxidation of LD on electrode surface and in incorporation with MWCNTs illustrated satisfactory synergic electrocatalytical properties which leads to sensitive detection of LD. Limit of detection (LOD), sensitivity and linear range were 2 nM, 2.26 μAμM-1 and 0.9-35 μM respectively which in comparison to other enzymatic or non-enzymatic sensors, were completely acceptable.
