Valganciclovir is an antiviral agent that prevents viral proliferation in the body. It is used in the treatment of in AIDS patients and prevent cytomegalovirus in patients who have had organ transplants.Determination of drug concentration plays a major role in controlling the quality of the drug and has a significant impact on overall health. Some methods for determination of drug concentration based on the use of chromatographic techniques such as HPLC and LC/MS have been reported for the determination of VAL. Most of these methods are tedious and time consuming involving derivatization with Chloroacetaldehyde, complex sample preparation by solid-phase extraction, and other methods of extraction prior to final analysis. Electrochemical sensors have found wide applications in medical, biological and environmental fields due to their excellent sensitivity, rapid response, simplicity, low cost and in vivo detection. Metals in the nanometer range provide three important functions for electroanalysis: the roughening of the conductive sensing interface, catalytic properties, and conductivity properties. Nanowires have many interesting properties that are not seen in bulk or 3D materials. This is due to electrons in nanowires are quantum confined laterally and thus occupy energy levels that are different from the traditional continuum of energy levels or bands found in bulk materials.Peculiar features of this quantum confinement exhibited by certain nanowires such as carbon nanotubes manifest themselves in discrete values of the electrical conductance. Such discrete values arise from a quantum mechanical restraint on the number of electrons that can travel through the wire at the nanometer scale.A sensitive electrochemical method for determination of Valganciclovir is developed using a Ni-Co multilayer nanowire modified carbon paste electrode. The effects of scan rate and pH on electrode response were investigated. Operational parameters have been optimized. Vast linear r
