Exercise increases the pain threshold in healthy people. However, the pain threshold modulation efect of exercise and hawthorn is unclear because of its potential benefts in people with persistent pain, including those with Alzheimer’s disease. Accordingly, after the induction of Alzheimer’s disease by trimethyl chloride, male rats with Alzheimer’s disease were subjected to a 12-week training regimen consisting of resistance training, swimming endurance exercises, and combined exercises. In addition, hawthorn extract was orally administered to the rats. Then, their pain threshold was evaluated using three Tail-fick, Hot-plate, and Formalin tests. Our results showed that Alzheimer’s decreased the pain threshold in all three behavioral tests. Combined exercise with hawthorn consumption had the most statistically signifcant efect on Alzheimer’s male rats’ pain threshold in all three experiments. A combination of swimming endurance and resistance exercises with hawthorn consumption may modulate hyperalgesia in Alzheimer’s rats. Future studies need to determine the efects of these factors on the treatment and/or management of painful conditions.
