Abstract objective: Exercise is one of the important indicators involved in metabolic control, obesity prevention and homeostasis control, and the first line of treatment to deal with metabolic syndrome is weight loss caused by physical activity, because these lifestyle changes improve the components of this disease. The aim of this study was to investigate the effect of combined exercises on metabolic indices in women with metabolic syndrome. methods: This study was conducted as a clinical trial in postmenopausal women with metabolic syndrome in one intervention groups and a control group. The people in the intervention group underwent an exercise program for 8 weeks and three sessions a week (the aerobic exercise program included running on a treadmill for 20 minutes with an intensity equal to 60 to 70% of the reserve heart rate, as well as resistance exercises with an intensity equal to 70% of one repetition. maximum) and the control group continued its routine program. Blood factors were measured before and after the last training session. One-way analysis of variance was used to analyze the data. results: There was a significant difference in the intra-group changes of the studied variables (HDL, LDL, TG, FBS, TC) in the intervention group (P≥0.05). The results of covariance analysis showed that there is a significant difference between the two groups in the indices (HDL, LDL, TG, FBS, TC) in the post-test (P<0.05). Conclusion: It seems that combined exercises have a positive effect on metabolic indices in patients with metabolic syndrome and can be considered as a treatment method in these cases.