hemainaimofthisarticleistostudyquantitativestructure of finite simple exceptional groups F4(2n) with n > 1. Here, we prove that the finite simple exceptional groups F4(2n), where 24n +1 is a prime number with n > 1 a power of 2, can be uniquely determined by their orders and the set of the number of elements with the same order. In conclusion, we give a positive answer to J. G. Thompson’s problem for finite simple exceptional groups F4(2n).