The main aim of this study was to determine the sero-prevalence of Toxoplasma gondii infection in domestic goats in western Iran. Three-hundred sixty blood samples of goats were collected in hamedan province.14.4% of the sera were positive using ELISA. There was a significant differences between infection rate, history of abortion, and different climate; unlike to age groups and gender. In conclusion, this is the first report of T. gondii infection in goats in western Iran. The results indicate that toxoplasmosis may partly be responsible for abortion and economic losses in goat husbandry in this region