Recently, solidification of floating drop rnicroextraction (SFODME} as a powerful, rapid and inexpensive new mode of liquid-phase rnicroextraction [LPl'vTE} has been developed. In SFODME small volume of an organic solvent is floated on the surface of an aqueous solution. After the completion of the extraction by proper stiringg, the organic solvent is solidified by placing the vial in an ice hath. Finally, the melted droplet is used for analyte determination. Quantification of curctnnin, the principal cuncuminoid of turmeric, is of interest due to its anti- inflammatory, antioxidant and anti-cancerous properties. Different methods have been used for curcumin determination. Important extraction parameters such as type and volume of organic solvent, temperature, salt addition and extraction time on the extraction recovery were investigated and optimized Under the optimized extraction conditions a linear range of ll. {l[l?- 1.5 pg m]..'l, RSD of 3.13 “/6 and an enhancement factor of 659 For curcumin were achieved. A limit of detection of l}.l}l)2 ug mL']curcumin were obtained for the method. The method was successfully applied to the analysis of curcumin in human urine samples.
