The severe side effects of systemic high doses of chemotherapy, as well as the development of drug resistance, make anticancer therapy less safe and effective. As a result, novel strategies for improving anticancer medication therapeutic index by targeted administration to tumor locations are constantly being researched and developed. Drug nanocarriers efficiently improve the targeting of diseased areas in the body and can enhance drug efficacy [1]. Among a variety of options, polymer nanoparticles are a potential option because they can be made up of smart materials that respond to environmental influences and change their characteristics appropriately, allowing for targeted drug delivery. Functional nanocarriers combining multi-drug release and other therapeutic strategies for synergistic tumor therapy may be an effective strategy for the accurate and efficient treatment of tumors [2]. This paper reports on a synthesis of a pH-responsive polymers for the controlled release of doxorubicin (DOX) and methylene blue (MB). DOX, and MB drugs were chosen as anticancer drugs and drug treatments for Alzheimer's, respectively. Proposed a pH-responsive polymer nanoparticles consist of chitosan, and alginate, which are natural and biocompatible polymers. To achieve the best performance, the formulation of the pH-responsive polymer nanoparticles was optimized by using aerosol method. Then, the in vitro release of two drugs at neutral and acidic pH was investigated using UV-Vis spectrometer. Under the optimized conditions, the loading amount of DOX, and MB into the polymer nanoparticles was 41.42 mg g -1 and 2.28 mg g -1 , respectively. In vitro release experiments showed that the release of DOX, and MB from polymer nanoparticles in acidic pH was higher compared to neutral pH. Therefore, DOX, and MB-loaded pH-responsive polymer nanoparticles based on chitosan, and alginate are a promising sustainable delivery system for cancer, and Alzheimer's therapy.
