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Abbas Afkhami

Abbas Afkhami

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId: 7003454553
HIndex:
Faculty: Faculty of Chemistry and Petroleum Sciences
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Phone:

Research

Title
Glucose cross-linked temperature-responsive gelatine hydrogel for targeted delivery of curcumin anticancer drug
Type
Presentation
Keywords
-
Year
2021
Researchers ، Tayyebeh Madrakian ، Abbas Afkhami ، Mazaher Ahmadi ، Leila Gholami

Abstract

In this work, a temperature-responsive hydrogel was synthesized based on a glucose-cross-linked gelatine. Polydopamine nanoparticles were incorporated into the hydrogel as NIR light chromophores. pH-responsive chitosan coated curcumin anticancer drug nanocapsules were also incorporated in the hydrogel to enable dual-stimuli sensitive delivery. The results showed that the drug release was higher at acidic pH values. However, it was not considerable at 37 ᵒC. A 940 nm NIR laser was used to heat-up the hydrogel. The results showed that under laser irradiation the drug release was significant at acidic pH values