We develop silicon quantum dots modified histidine graphene quantum dots as novel biological carrier for target drug delivery. To effectively treat this aggressive tumor, a multi-target receptor tyrosine kinase inhibitor, sunitinib base, was efficiently loaded on nano-delivery system. The purpose of this study was to prepare silicon quantum dots modified histidine graphene quantum dots (Si-QDs @His-GQDs) as a novel carrier for selective intracellular delivery of Sunitinib. In our study, a pH-sensitive drug delivery system consisted of Si-QDs @His-GQDs have been successfully synthesized as the drug carriers. Because of the synthesis of carrier under neutral conditions, Si-QDs @His-GQDs show the pH-sensitive load and release performance based on the slight difference between tumor (weakly acid) and normal tissue (weakly alkaline). And before reaching tumor site, the drug delivery system shows good drug retention. The excellent biocompatibility and selective release performance of the carrier, is expected to be promising in the potential application of cancer treatment.
