Cefixime is a broad-spectrum cephalosporin antibiotic that was used for the treatment of bacterial infections. Graphene quantum dots are graphene sheets smaller than 100 nm, that they are an excellent candidate for the construction of nano scaled optical and electronic devices. Also, electrochemical methods have confirmed to be sensitive for the analysis of drugs in human body fluids. In this project, application of graphene quantum dot nanocomposite and Au nanoparticles as a modifier for the determination of cefixime is investigated. The morphology and performance of the sensor were characterized with different techniques such as X-ray diffraction spectrometry, Fourier transform infrared spectrometry, cyclic voltammetry, differential pulse voltammetry. Under the optimized conditions, cefixime gave linear range and detection limit response over the range of 0.02-200.0 and 0.01 μmol L-1, respectively. The application of the fabricated electrode was demonstrated by measuring the concentration of cefixime in pharmaceutical and plasma samples with satisfactory results.
