Doxorubicin (DOX) also known as hydroxydaunorubicin, is an anthracycline antibiotic and a drug used in cancer chemotherapy. It works by intercalating DNA and could cause some adverse effects such as life-threatening heart. Therefore, the development of sensitive and reliable analytical methods for the determination of DOX is a basic requirement for the study of this analyte in different types of samples with complex matrices [1]. Resonance light scattering (RLS) has emerged as a powerful optical technique based on elastic light-scattering. Due to the advantages of high sensitivity, rapidness, simplicity and convenience. In the past few years, nano composite materials have been subjected to extensive research as the combination of different nano scale functionalities are capable of endowing the substrate with enhanced properties and thus have great application potentials in various fields. The core/shell nanostructure is an ideal composite system that combines the advantages of core and shell and has shown enhanced physical and chemical properties. In this study magnetic Fe 3 O 4 nanoparticles (MNPs) were synthesized by the Solvothermal method and then modified with APTES [2]. Amino groups coated magnetic Fe 3 O 4 nanoparticles were covered with platinum. Physical characteristics of Pt@ Fe 3 O 4 were studied using SEM and XRD measurements. The magnitude of RLS intensity of the Pt@Fe 3 O 4 ex em dition: ultra-sonication time: 30 min, pH 5, nanoparticle concentration : 10 mg L -1 . The linear dynamic range was established from 0.05 -7 mg L -1 of Doxorubicine and the limit of detection was found to be 0.0028 mg L -1 using proposed method.
